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Colposcopy and Biopsy: Procedure, Preparation and Results

A colposcopy is a close look at your cervix using a magnifying instrument, often done after an abnormal screening test. This guide explains why it is advised, how to prepare, what a biopsy involves and how to read your results with your doctor.

What is a colposcopy?

A colposcopy is a close examination of your cervix, the opening of the womb. The doctor uses a colposcope, which is a magnifying instrument with a bright light. It stays outside your body. It lets the doctor see changes on the cervix that are too small to see with the naked eye.

If an area looks unusual, the doctor may take a tiny piece of tissue. This is called a biopsy. The sample goes to a laboratory, where a pathologist studies it under a microscope. A colposcopy is a test to find out more. Being asked to have one does not mean you have cancer.

Why you may be asked to have one

Most women are referred after a screening test. Common reasons include:

  • An abnormal result on a Pap smear or HPV test
  • A cervix that looked unusual during an internal examination
  • Bleeding after sex or between periods that has no clear cause
  • Genital warts or an unusual growth on the cervix, vagina or vulva
  • Follow-up after earlier treatment for cervical cell changes

Most abnormal screening results are caused by cell changes linked to human papillomavirus (HPV), a very common infection. Many of these changes are mild and settle without treatment. The colposcopy helps your doctor decide whether you need treatment, repeat testing or nothing at all.

How to prepare

Choosing the day

Try to book the test for a day when you are not having your period, as heavy bleeding makes the cervix harder to see. If your period starts unexpectedly, call the clinic and ask whether to reschedule.

The day or two before

Doctors usually advise you to avoid sex, tampons, vaginal creams and douching for 24 to 48 hours before the test. Tell the doctor if you are pregnant or might be, if you take blood-thinning medicine, or if you have any allergies. A colposcopy can be done safely in pregnancy, but the doctor decides whether a biopsy is needed or can wait until after delivery.

What happens during the procedure

The test is done in an outpatient room and usually takes 15 to 20 minutes. You can normally go home soon afterwards.

  1. You undress from the waist down and lie on an examination couch with your legs supported.
  2. The doctor gently inserts a speculum into the vagina, the same instrument used for a Pap smear.
  3. The colposcope is placed near the opening of the vagina. It does not go inside.
  4. A weak vinegar-like solution, and sometimes an iodine solution, is dabbed on the cervix. Abnormal areas change colour. You may feel mild stinging.
  5. If needed, the doctor takes one or more small biopsies. This can feel like a sharp pinch or a cramp.
  6. Any bleeding is stopped with pressure or a special paste, and the speculum is removed.

You can ask for the test to be paused at any time. Many clinics allow a family member or a female attendant to stay with you.

Types of biopsy

The type of sample depends on what the doctor sees. Your doctor will explain which one is planned and why.

TypeWhat is takenAnaesthesia
Punch biopsyA tiny piece from the surface of the cervixOften none, sometimes local
Endocervical samplingCells scraped from the canal of the cervixUsually none
Loop excision (LEEP or LLETZ)A thin layer removed with a heated wire loopLocal
Cone biopsyA cone-shaped piece of the cervixRegional or general

After the test and getting your results

Recovery

If no biopsy was taken, you can return to normal activities straight away. After a biopsy, you may have mild cramps, light spotting or a dark discharge for a few days. The dark colour comes from the paste used to control bleeding. Use a sanitary pad instead of a tampon. Your doctor will tell you how long to avoid sex, swimming and heavy exercise. Recovery takes longer after a loop excision or cone biopsy.

Results

Biopsy reports usually take one to two weeks, though this varies between laboratories. The report may say the tissue is normal, or it may describe cell changes graded as CIN 1, CIN 2 or CIN 3. These are not cancer. They show how much of the lining of the cervix is affected by abnormal cells. Low-grade changes are often simply watched. Higher-grade changes are usually treated to stop them from turning into cancer over time. In a small number of women, the biopsy finds cancer, and the doctor then plans further tests and care.

Costs vary by city, hospital and the type of biopsy. Keep all your reports and take them to your routine gynecological check-up so that follow-up tests are done on time.

When to see a gynecologist

Some bleeding and discomfort are expected after a biopsy. Contact a doctor promptly if you notice any of the following:

  • Heavy bleeding that soaks more than one pad an hour or contains large clots
  • Bleeding that lasts longer than a week
  • Fever or chills
  • Vaginal discharge that smells bad
  • Strong pain in the lower abdomen that does not ease with the pain relief your doctor suggested

Even if you have not had a colposcopy, see a gynecologist if you have bleeding after sex, bleeding between periods, bleeding after menopause or pelvic pain that does not go away. This article gives general information only. It cannot replace an examination and advice from a qualified doctor.

This page is general information for readers in India. It is not medical advice. Speak to a qualified gynecologist about your own health.

Questions about colposcopy and biopsy

Is a colposcopy painful?

Most women describe it as uncomfortable more than painful, similar to a Pap smear that lasts a little longer. The solution on the cervix can sting, and a biopsy may cause a brief pinch or cramp. Ask your doctor beforehand whether taking a simple painkiller before the appointment is suitable for you.

Does needing a colposcopy mean I have cancer?

No. Colposcopy is a follow-up test, and most women who have one do not have cancer. It is usually advised because screening found cell changes or HPV that need a closer look. Finding and treating such changes early is the way cervical cancer is prevented.

How long does bleeding last after a cervical biopsy?

Light spotting or a brownish discharge commonly lasts a few days and sometimes up to a week. After a loop excision it may continue for longer. Bleeding heavier than a normal period, large clots or a foul smell are not expected and should be reported to your doctor.

Can I have a colposcopy during my period?

Light spotting is usually not a problem, but heavy flow can hide the cervix and make the test less reliable. Most clinics prefer to see you once the bleeding has stopped. If your period arrives close to the appointment, phone ahead and follow the clinic's advice.

When can I have sex after a colposcopy?

If no biopsy was taken, there is usually no need to wait. After a biopsy, doctors generally advise avoiding intercourse until bleeding and discharge have stopped, which is often about a week. After loop excision or cone biopsy the wait is longer, commonly around four weeks, as your doctor directs.

Can colposcopy affect future pregnancy?

A colposcopy with a small punch biopsy is not known to affect fertility or pregnancy. Larger treatments that remove part of the cervix, such as cone biopsy, may slightly raise the chance of early delivery in a later pregnancy. Tell your obstetrician about any past cervical treatment.